Learning Outcomes
Introduction to Pathophysiology
Define pathophysiology and demonstrate an understanding of the scope of science of pathophysiology.
Define and use appropriately the various pathophysiological terms.
Altered Cellular and Tissue Biology
Describe cellular structure, components, organelles and their functions (review).
Define and distinguish cellular adaptation versus cellular injury.
Describe the cellular adaptations made in each of the following processes: atrophy, hypertrophy, hyperplasia, dysplasia (atypical hyperplasia), and metaplasia.
Discuss physiologic versus pathogenic cellular adaptations.
Describe the mechanisms of cellular injury that can occur as a result of the following causes: hypoxia, chemicals, free radicals, infectious agents, asphyxial injuries, immunologic and inflammatory responses, genetic factors, nutritional imbalances, and physical trauma.
Describe the cellular damage incurred in reperfusion (reoxygenation) injury.
Describe the characteristics of the following intentional and unintentional injuries: blunt force injuries, sharp force injuries, gunshot wounds, and asphyxial injuries.
Define the following terms associated with blunt force injuries: contusion, hematoma, abrasion, laceration, and fracture.
Define the following terms association with sharp force injuries: incised wound, stab wound, puncture wound, and chopping wound.
Define the following terms associated with gunshot and asphyxial injuries: entrance wound, exit wound, suffocation, strangulation, drowning, and chemical asphyxiation.
Define necrosis.
Identify and describe the mechanism and resulting damage of coagulative, liquifactive, caseous, fat, and gangrenous necrosis.
Compare and contrast cellular necrosis with apoptosis.
Describe the cellular mechanisms of normal degenerative changes of aging.
Describe the clinical manifestations of somatic death.
Definitions: Altered Cellular and Tissue Biology
